Polysialylation of Neural Cell Adhesion Molecules
نویسندگان
چکیده
منابع مشابه
Neural GPI-anchored cell adhesion molecules.
When first identified, neural cell adhesion molecules (neural CAMs) were thought to act simply by providing cell surfaces with differential adhesion properties. In the decades following the identification of the first neural CAMs, it has been realized that these proteins are actually involved in very complex processes such as axon guidance, neuronal migration, neurite outgrowth and fasciculatio...
متن کاملThe Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis
Despite its multi-faceted role in neurodegenerative diseases, the physiological function of the prion protein (PrP) has remained elusive. On the basis of its evolutionary relationship to ZIP metal ion transporters, we considered that PrP may contribute to the morphogenetic reprogramming of cells underlying epithelial-to-mesenchymal transitions (EMT). Consistent with this hypothesis, PrP transcr...
متن کاملAdhesion molecules in skeletogenesis: II. Neural cell adhesion molecules mediate precartilaginous mesenchymal condensations and enhance chondrogenesis.
Neural cell adhesion molecules (NCAM) was expressed transiently by mesenchymal cells in precartilaginous condensations of the embryonic chicken limb but was lost upon differentiation into cartilage. Consequently, NCAM was present in the periphery of the limb anlagen but was absent in the cartilaginous center of the growing limb. To determine NCAM function in limb bud chondrogenesis we incubated...
متن کاملCellular signalling mechanisms of neural cell adhesion molecules.
Neural cell adhesion molecules of the immunoglobulin superfamily are multidomain proteins involved in important cellular events pertinent to development and adult neurological function. This review attempts to give a concise overview of the complex intracellular signaling pathways enabling neural cell adhesion molecules NCAM and L1 to regulate axon growth, guidance, and synaptic plasticity. Rec...
متن کاملCell Adhesion Molecules in Neural Stem Cell and Stem Cell-Based Therapy for Neural Disorders
Neural stem/progenitor cells (NS/PCs), found in both the developing and the adult mamma‐ lian central nervous system (CNS), are a heterogeneous population of multipotent cells with the potential to self-renew by symmetric cell division or to differentiate into neurons, astrocytes and oligodendrocytes through asymmetric cell division (Gage, 2000; Alvarez-Buylla et al., 2001; Temple, 2001; Götz a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1990
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.2.430